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Article

Germline functional variants contribute to somatic mutation and outcomes in neuroblastoma.

Nature communications - 27 Sept 2024

Seo Eun Seop, Lee Ji Won, Lim Jinyeong, Shin Sunghwan, Cho Hee Won, Ju Hee Young, Yoo Keon Hee, Sung Ki Woong, Park Woong-Yang

Abstract excerpt

Germline genetic context may play a significant role in the development and evolution of cancer, particularly in childhood cancers such as neuroblastoma. This study investigates the role of putatively functional germline variants in neuroblastoma, even if they do not directly increase disease risk. Our whole-exome sequencing analysis of 125 patients with neuroblastoma reveals a positive correlation between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39333105
DOI: 10.1038/s41467-024-52128-5
PMCID: PMC11437149

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