Article

Saturation variant interpretation using CRISPR prime editing

2021-05-14

Abstract excerpt

Over the last decade, next generation sequencing has become widely implemented in clinical practice. However, as genetic variants of uncertain significance (VUS) are frequently identified, the need for scaled functional interpretation of such variants has become increasingly apparent. One method to address this is saturation genome editing (SGE), which allows for scaled multiplexed functional assessment of single...

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Literature Corpus work: a30d1b37-dcb4-568c-ac9c-2d8b3d9f1a42
DOI: 10.1101/2021.05.11.443710

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