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Article

Identifying causal genes for stroke via integrating the proteome and transcriptome from brain and blood.

Journal of translational medicine - 21 Apr 2022

Wu Bang-Sheng, Chen Shu-Fen, Huang Shu-Yi, Ou Ya-Nan, Deng Yue-Ting, Chen Shi-Dong, Dong Qiang, Yu Jin-Tai

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have revealed numerous loci associated with stroke. However, the underlying mechanisms at these loci in the pathogenesis of stroke and effective stroke drug targets are elusive. Therefore, we aimed to identify causal genes in the pathogenesis of stroke and its subtypes. METHODS: Utilizing multidimensional high-throughput data generated, we integrated...

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Identifiers

PMID: 35449099
DOI: 10.1186/s12967-022-03377-9
PMCID: PMC9022281

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