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Article

In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis.

Emerging microbes & infections - 1 Dec 2024

Shen Siquan, Tang Chengkang, Yang Weiwei, Ding Li, Han Renru, Shi Qingyu, Guo Yan, Yin Dandan, Hu Fupin

Abstract excerpt

Ceftazidime-avibactam (CZA) is employed for the treatment of infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP). Resistance to CZA is frequently linked to point mutations in the blaKPC. We conducted in vitro simulations of in vivo blaKPC mutations using CZA. Four pre-therapy KPC-KP isolates (K1, K2, K3, and K4) were evaluated, all initially exhibited susceptibility to CZA...

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Identifiers

PMID: 38743401
DOI: 10.1080/22221751.2024.2356146
PMCID: PMC11151810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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