Suboptimal ceftazidime-avibactam exposure drives sequential blaKPC mutations and intra-host coexistence of Klebsiella pneumoniae harboring distinct variants leading to persistent infection.

Abstract excerpt

KPC-producing Klebsiella pneumoniae infections are a rising global health threat. The factors driving blaKPC mutations during treatment and their contribution to infection persistence remain unclear. This study characterized blaKPC evolution under reduced-dose ceftazidime-avibactam therapy for renal impairment, using 10 sequential K. pneumoniae isolates (showing resistance shifts) collected from a single patient...

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