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Emergence of ceftazidime-avibactam resistance due to a novel blaKPC-2 mutation during treatment of carbapenem-resistant Klebsiella pneumoniae infections.

Journal of infection and public health - 1 May 2022

Liao Quanfeng, Deng Jin, Feng Yu, Zhang Weili, Wu Siying, Liu Ya, Che Huijuan, Xie Yi

Abstract excerpt

OBJECTIVE: Klebsiella pneumoniae carbapenemase (KPC)-producing K.pneumoniae has represented a serious health problem in worldwide. The resistance to ceftazidime-avibactam (CAZ-AVI) began to emerge since its approval in 2015. We aim to explore the resistance mechanism of CAZ-AVI. METHODS: Phenotypic test and whole-genome sequencing (WGS) analysis were performed in KP-HX0917 and KP-HX1016 Klebsiella pneumoniae...

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PMID: 35461077
DOI: 10.1016/j.jiph.2022.04.002

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