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A large-scale surveillance revealed that KPC variants mediated ceftazidime-avibactam resistance in clinically isolated Klebsiella pneumoniae.

Microbiology spectrum - 6 Aug 2024

Qiao Sai, Xin Shaojun, Zhu Yufeng, Zhao Feng, Wu Heng, Zhang Jingjing, Yao Bingyan, Yu Yunsong, Fu Ying, Jiang Yan, Xie Xinyou, Zhang Jun

Abstract excerpt

To monitor the resistance rate and gain a deeper understanding of the resistance mechanisms, we conducted over a 2-year surveillance focusing on the Klebsiella pneumoniae associated with the clinical usage of ceftazidime-avibactam (CZA) in a teaching hospital. A total of 4,641 K. pneumoniae isolates were screened to identify the CZA resistance through antimicrobial susceptibility testing. Comprehensive analyses,...

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Identifiers

PMID: 38958437
DOI: 10.1128/spectrum.00258-24
PMCID: PMC11302327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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