Article
Evolution of ceftazidime-avibactam resistance driven by mutations in double-copy blaKPC-2 to blaKPC-189 during treatment of ST11 carbapenem-resistant Klebsiella pneumoniae.
mSystems - 22 Oct 2024
Zhang Xiaofan, Xie Yinrong, Zhang Ying, Lei Tailong, Zhou Longjie, Yao Jiayao, Liu Lin, Liu Haiyang, He Jintao, Yu Yunsong, Tu Yuexing, Li Xi
Abstract excerpt
Klebsiella pneumoniae carbapenemase (KPC) variants can contribute to resistance to ceftazidime-avibactam (CZA) in Klebsiella pneumoniae (KP). However, two-copy KPC variant-mediated resistance to CZA has rarely been reported to date. Here, we aimed to clarify the evolutionary trajectory of CZA resistance driven by mutations in double-copy blaKPC-2 to blaKPC-189 carried by the tandem core structure...
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