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ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis

14 May 2024

Abstract excerpt

BACKGROUND AND PURPOSE: ApTOLL is an aptamer selected to antagonize toll-like receptor 4 (TLR4), a relevant actor for innate immunity involved in inflammatory responses in multiple sclerosis (MS) and other diseases. The currently available therapeutic arsenal to treat MS is composed of immunomodulators but, to date, there are no (re)myelinating drugs available in clinics. In our present study, we studied the...

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PMID: 38742374
DOI: 10.1111/bph.16399

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