Article
comorbidPGS: An R Package Assessing Shared Predisposition between Phenotypes Using Polygenic Scores.
Human heredity - 1 Jan 2024
Pascat Vincent, Zudina Liudmila, Ulrich Anna, Maina Jared G, Kaakinen Marika, Pupko Igor, Bonnefond Amélie, Demirkan Ayse, Balkhiyarova Zhanna, Froguel Philippe, Prokopenko Inga
Abstract excerpt
INTRODUCTION: Polygenic score (PGS) is a valuable method for assessing the estimated genetic liability to a given outcome or genetic variability contributing to a quantitative trait. While polygenic risk scores are widely used for complex traits, their application in uncovering shared genetic predisposition between phenotypes, i.e., when genetic variants influence more than one phenotype, remains limited....
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