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Article

GenRisk: a tool for comprehensive genetic risk modeling.

Bioinformatics (Oxford, England) - 28 Apr 2022

Aldisi Rana, Hassanin Emadeldin, Sivalingam Sugirthan, Buness Andreas, Klinkhammer Hannah, Mayr Andreas, Fröhlich Holger, Krawitz Peter, Maj Carlo

Abstract excerpt

SUMMARY: The genetic architecture of complex traits can be influenced by both many common regulatory variants with small effect sizes and rare deleterious variants in coding regions with larger effect sizes. However, the two kinds of genetic contributions are typically analyzed independently. Here, we present GenRisk, a python package for the computation and the integration of gene scores based on the burden of...

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PMID: 35266528
DOI: 10.1093/bioinformatics/btac152
PMCID: PMC9048672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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