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Article

Shared genetic architecture highlights the bidirectional association between major depressive disorder and fracture risk

8 May 2024

Abstract excerpt

Background There is limited evidence suggesting that osteoporosis might exacerbate depressive symptoms, while more studies demonstrate that depression negatively affects bone density and increases fracture risk. Aims To explore the relationship between major depressive disorder (MDD) and fracture risk. Methods We conducted a nested case‐control analysis (32 670 patients with fracture and 397 017 individuals...

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PMID: 38737893
DOI: 10.1136/gpsych-2023-101418

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