Article
Genetic basis of falling risk susceptibility in the UK Biobank Study.
Communications biology - 30 Sept 2020
Trajanoska Katerina, Seppala Lotta J, Medina-Gomez Carolina, Hsu Yi-Hsiang, Zhou Sirui, van Schoor Natasja M, de Groot Lisette C P G M, Karasik David, Richards J Brent, Kiel Douglas P, Uitterlinden Andre G, Perry John R B, van der Velde Nathalie, Day Felix R, Rivadeneira Fernando
Abstract excerpt
Both extrinsic and intrinsic factors predispose older people to fall. We performed a genome-wide association analysis to investigate how much of an individual's fall susceptibility can be attributed to genetics in 89,076 cases and 362,103 controls from the UK Biobank Study. The analysis revealed a small, but significant SNP-based heritability (2.7%) and identified three novel fall-associated loci...
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