Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2 Diabetes.

JAMA cardiology - 1 Apr 2025

Ravi Akshaya, Koyama Satoshi, Cho So Mi Jemma, Haidermota Sara, Hornsby Whitney, Ellinor Patrick T, Natarajan Pradeep

Abstract excerpt

Importance: Treatment to lower high levels of low-density lipoprotein cholesterol (LDL-C) reduces incident coronary artery disease (CAD) risk but modestly increases the risk for incident type 2 diabetes (T2D). The extent to which genetic factors across the cholesterol spectrum are associated with incident T2D is not well understood. Objective: To investigate the association of genetic predisposition to increased...

Read the complete abstract on PubMed

Topics

Humans
Diabetes Mellitus, Type 2
Female
Male
Cholesterol, LDL
Middle Aged
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Prospective Studies

Incidence

Proprotein Convertase 9

Aged

Hyperlipoproteinemia Type II

United Kingdom

Risk Factors

Apolipoprotein B-100

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 39813027
DOI: 10.1001/jamacardio.2024.5072
PMCID: PMC11983226

Genes

CAD
FH
APOB
PCSK9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2 Diabetes.PMID 39813027Read ↗

Type-2 diabetes with low LDL-C: genetic insights into a unique phenotypeSemantic proximity Read ↗

Phenotypic and Genetic Characterization of Lower LDL Cholesterol and Increased Type 2 Diabetes Risk in the UK Biobank.Semantic proximity Read ↗

Cardiovascular health, genetic predisposition, and lifetime risk of type 2 diabetes.Semantic proximity Read ↗

Type 2 diabetes genetic risk and incident diabetes across diabetes risk enhancers.Semantic proximity Read ↗

Familial Hypercholesterolemia Variant and Cardiovascular Risk in Individuals With Elevated CholesterolSemantic proximity Read ↗

Polygenic Hyperlipidemias and Coronary Artery Disease RiskSemantic proximity Read ↗

Polygenic Hyperlipidemias and Coronary Artery Disease Risk.Semantic proximity Read ↗

A precision medicine approach to coronary artery disease risk prediction and mitigation in people with type 2 diabetesSemantic proximity Read ↗

Associations of Combined Genetic and Lifestyle Risks With Incident Cardiovascular Disease and Diabetes in the UK Biobank Study.Semantic proximity Read ↗

Polygenic Risk Score for Low-Density Lipoprotein Cholesterol Is Associated With Risk of Ischemic Heart Disease and Enriches for Individuals With Familial Hypercholesterolemia.Semantic proximity Read ↗

Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis.Semantic proximity Read ↗

Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.