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Article

Common and low-frequency genetic variants in the PCSK9 locus influence circulating PCSK9 levels.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2012

Chernogubova Ekaterina, Strawbridge Rona, Mahdessian Hovsep, Mälarstig Anders, Krapivner Sergey, Gigante Bruna, Hellénius Mai-Lis, de Faire Ulf, Franco-Cereceda Anders, Syvänen Ann-Christine, Troutt Jason S, Konrad Robert J, Eriksson Per, Hamsten Anders, van 't Hooft Ferdinand M

Abstract excerpt

OBJECTIVE: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that influences plasma low-density lipoprotein concentration and susceptibility to coronary heart disease. Circulating PCSK9 levels show considerable interindividual differences, but the factors responsible for this variation are largely unknown. METHODS AND RESULTS: We analyzed circulating PCSK9 levels in 4 cohorts of...

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Identifiers

PMID: 22460556
DOI: 10.1161/ATVBAHA.111.240549

Genes

PCSK9

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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