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Article

The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis.

Diabetologia - 1 Sept 2015

Bonnefond Amélie, Yengo Loïc, Le May Cédric, Fumeron Fréderic, Marre Michel, Balkau Beverley, Charpentier Guillaume, Franc Sylvia, Froguel Philippe, Cariou Bertrand

Abstract excerpt

AIMS/HYPOTHESIS: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a critical regulator of cholesterol homeostasis. PCSK9 inhibitors are being actively developed to lower LDL-cholesterol levels. However, there are conflicting data regarding the consequences of Pcsk9 deficiency on glucose h...

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Source

Identifiers

PMID: 26049403
DOI: 10.1007/s00125-015-3659-8

Genes

PCSK9

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26049403-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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