Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The pathogenesis of therapy-related myeloid neoplasms from TP53-mutant clonal hematopoiesis.

Leukemia - 1 Feb 2026

Fullin Jonas, Topçu Ebru, Zielińska Karolina A, Schimmer Roman R, Klemm Nancy, Koch Christian, Caiado Francisco, Lock Melissa, Doerdelmann Cyril, Bühler Marco M, Tchinda Joelle, Kurppa Kari J, Borsig Lubor, Jones Philip H, Lopes Massimo, Manz Markus G, Boettcher Steffen

Abstract excerpt

Therapy-related acute myeloid leukemia and myelodysplastic neoplasms (t-AML/MDS) are devastating complications of chemo- or radiation therapy in patients treated for an unrelated primary malignancy. Cancer patients with TP53-mutant hematopoietic stem and progenitor cells (HSPCs) - a condition termed clonal hematopoiesis (CH) - are at a particularly high risk for t-AML/MDS. However, the pathogenesis of TP53-mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clonal Hematopoiesis
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Hematopoietic Stem Cells

Share to Leukemia, Myeloid, Acute

Share to Myelodysplastic Syndromes

Share to Neoplasms, Second Primary

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 41407825
DOI: 10.1038/s41375-025-02839-5
PMCID: PMC12875862

Genes

TP53
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The pathogenesis of therapy-related myeloid neoplasms from TP53-mutant clonal hematopoiesis.PMID 41407825Read ↗

A line in shifting sand: Can we define and target TP53 mutated MDS?Semantic proximity Read ↗

Acute Myeloid Leukemia and Myelodysplastic Syndromes with TP53 Aberrations - A Distinct Stem Cell Disorder.Semantic proximity Read ↗

Deciphering <i>TP53</i> mutant Cancer Evolution with Single-Cell Multi-OmicsSemantic proximity Read ↗

BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation.Semantic proximity Read ↗

Comparison of<i>TP53</i>Mutations in Myelodysplasia and Acute Leukemia Suggests Divergent Roles in Initiation and ProgressionSemantic proximity Read ↗

Comparison of TP53 mutations in myelodysplasia and acute leukemia suggests divergent roles in initiation and progressionSemantic proximity Read ↗

Nontransplant treatment approaches for myeloid neoplasm with mutated TP53.Semantic proximity Read ↗

Transplant for TP53-mutated MDS and AML: because we can or because we should?Semantic proximity Read ↗

Molecular and Clinical Insights into TP53-Mutated MDS and AML.Semantic proximity Read ↗

Molecular characterization and prognosis of mutant TP53 acute myeloid leukemia and myelodysplastic syndrome with excess blasts.Semantic proximity Read ↗

TP53-Mutated Myelodysplastic Syndrome and Acute Myeloid Leukemia: Biology, Current Therapy, and Future Directions.Semantic proximity Read ↗

p53 involvement in clonal hematopoiesis of indeterminate potentialSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.