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Article

A Novel Locus Predicts Spermatogenic Recovery among Childhood Cancer Survivors Exposed to Alkylating Agents.

Cancer research - 1 Sept 2020

Sapkota Yadav, Wilson Carmen L, Zaidi Asifa K, Moon Wonjong, Fon Tacer Klementina, Lu Lu, Liu Qi, Baedke Jessica, Dhaduk Rikeenkumar, Wang Zhaoming, Chemaitilly Wassim, Krasin Matthew J, Berry Fred B, Zhang Jinghui, Hudson Melissa M, Robison Leslie L, Green Daniel M, Yasui Yutaka

Abstract excerpt

Exposure to high doses of alkylating agents is associated with increased risk of impaired spermatogenesis among nonirradiated male survivors of childhood cancer, but there is substantial variation in this risk. Here we conducted a genetic study for impaired spermatogenesis utilizing whole-genome sequencing data from 167 nonirradiated male childhood cancer survivors of European ancestry from the St. Jude Lifetime...

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Share to Antineoplastic Agents, Alkylating
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32554749
DOI: 10.1158/0008-5472.CAN-20-0093
PMCID: PMC7731186

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