Article
The influence of genetic variation on late toxicities in childhood cancer survivors: A review.
Critical reviews in oncology/hematology - 1 Jun 2018
Clemens E, van der Kooi A L F, Broer L, van Dulmen-den Broeder E, Visscher H, Kremer L, Tissing W, Loonen J, Ronckers C M, Pluijm S M F, Neggers S J C M M, Zolk O, Langer T, Zehnhoff-Dinnesen A Am, Wilson C L, Hudson M M, Carleton B, Laven J S E, Uitterlinden A G, van den Heuvel-Eibrink M M
Abstract excerpt
INTRODUCTION: The variability in late toxicities among childhood cancer survivors (CCS) is only partially explained by treatment and baseline patient characteristics. Inter-individual variability in the association between treatment exposure and risk of late toxicity suggests that genetic variation possibly modifies this association. We reviewed the available literature on genetic susceptibility of late toxicity...
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