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Divergent and Compensatory Effects of BMP2 and BMP4 on the VSMC Phenotype and BMP4's Role in Thoracic Aortic Aneurysm Development.

Cells - 24 Apr 2024

Klessinger Daniel, Mamazhakypov Argen, Glaeser Sophie, Emig Ramona, Peyronnet Remi, Meier Lena, Proelss Kora, Marenne Katia, Smolka Christian, Grundmann Sebastian, Pankratz Franziska, Esser Philipp R, Moser Martin, Zhou Qian, Esser Jennifer S

Abstract excerpt

Vascular smooth muscle cells (VSMCs) play a key role in aortic aneurysm formation. Bone morphogenetic proteins (BMPs) have been implicated as important regulators of VSMC phenotype, and dysregulation of the BMP pathway has been shown to be associated with vascular diseases. The aim of this study was to investigate for the first time the effects of BMP-4 on the VSMC phenotype and to understand its role in the...

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Identifiers

PMID: 38727271
DOI: 10.3390/cells13090735
PMCID: PMC11083443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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