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Article

Stem cell signature in glioblastoma: therapeutic development for a moving target.

Journal of neurosurgery - 1 Feb 2015

Nakano Ichiro

Abstract excerpt

Tumor heterogeneity of adult high-grade glioma (HGG) is recognized in 3 major subtypes based on core gene signatures. However, the molecular signatures and clinical implications of glioma stem cells (GSCs) in individual HGG subtypes remain poorly characterized. Recently genome-wide transcriptional analysis identified two mutually exclusive GSC subtypes with distinct dysregulated signaling and metabolic pathways....

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Identifiers

PMID: 25397368
DOI: 10.3171/2014.9.JNS132253

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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