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Article

Stem cell signature in glioblastoma: therapeutic development for a moving target.

Journal of neurosurgery - 1 Feb 2015

Nakano Ichiro

Abstract excerpt

Tumor heterogeneity of adult high-grade glioma (HGG) is recognized in 3 major subtypes based on core gene signatures. However, the molecular signatures and clinical implications of glioma stem cells (GSCs) in individual HGG subtypes remain poorly characterized. Recently genome-wide transcriptional analysis identified two mutually exclusive GSC subtypes with distinct dysregulated signaling and metabolic pathways....

Topics

Brain Neoplasms
Cellular Reprogramming
Glioblastoma
Humans
Mesoderm
Neoplastic Stem Cells
Neuronal Plasticity
Neurons
Phenotype
Systems Biology
Translational Research, Biomedical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25397368
DOI: 10.3171/2014.9.JNS132253

Genes

GSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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