Article
In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene.
Nature communications - 11 Sept 2019
Peter Cyril J, Saito Atsushi, Hasegawa Yuto, Tanaka Yuya, Nagpal Mohika, Perez Gabriel, Alway Emily, Espeso-Gil Sergio, Fayyad Tariq, Ratner Chana, Dincer Aslihan, Gupta Achla, Devi Lakshmi, Pappas John G, Lalonde François M, Butman John A, Han Joan C, Akbarian Schahram, Kamiya Atsushi
Abstract excerpt
Many neuropsychiatric risk genes contribute to epigenetic regulation but little is known about specific chromatin-associated mechanisms governing the formation of neuronal connectivity. Here we show that transcallosal connectivity is critically dependent on C11orf46, a nuclear protein encoded in the chromosome 11p13 WAGR risk locus. C11orf46 haploinsufficiency was associated with hypoplasia of the corpus...
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