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Article

Impact of distinct FG nucleoporin repeats on Nup98 self-association.

Nature communications - 7 May 2024

Ibáñez de Opakua Alain, Pantoja Christian F, Cima-Omori Maria-Sol, Dienemann Christian, Zweckstetter Markus

Abstract excerpt

Nucleoporins rich in phenylalanine/glycine (FG) residues form the permeability barrier within the nuclear pore complex and are implicated in several pathological cellular processes, including oncogenic fusion condensates. The self-association of FG-repeat proteins and interactions between FG-repeats play a critical role in these activities by forming hydrogel-like structures. Here we show that mutation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38714656
DOI: 10.1038/s41467-024-48194-4
PMCID: PMC11076500

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