Article
Emerin self-assembly mechanism: role of the LEM domain.
The FEBS journal - 1 Jan 2017
Samson Camille, Celli Florian, Hendriks Kitty, Zinke Maximilian, Essawy Nada, Herrada Isaline, Arteni Ana-Andreea, Theillet François-Xavier, Alpha-Bazin Béatrice, Armengaud Jean, Coirault Catherine, Lange Adam, Zinn-Justin Sophie
Abstract excerpt
At the nuclear envelope, the inner nuclear membrane protein emerin contributes to the interface between the nucleoskeleton and the chromatin. Emerin is an essential actor of the nuclear response to a mechanical signal. Genetic defects in emerin cause Emery-Dreifuss muscular dystrophy. It was proposed that emerin oligomerization regulates nucleoskeleton binding, and impaired oligomerization contributes to the loss...
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