Loss of copy numbers of retrotransposons (HERVK) on chromosome 7p11.2 impacts EGFR (Epidermal Growth Factor Receptor)-induced phenotypes for platinum sensitivity and long-term survival in ovarian cancer-A study from the OVCAD consortium.

doi:10.1002/ijc.34976

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Loss of copy numbers of retrotransposons (HERVK) on chromosome 7p11.2 impacts EGFR (Epidermal Growth Factor Receptor)-induced phenotypes for platinum sensitivity and long-term survival in ovarian cancer-A study from the OVCAD consortium.

International journal of cancer - 1 Sept 2024

Fromhage Gesa, Obermayr Eva, Bednarz-Knoll Natalia, Van Gorp Toon, Welsch Eva, Polterauer Stephan, Braicu Elena Ioana, Mahner Sven, Sehouli Jalid, Vergote Ignace, Concin Nicole, Kurtz Stefan, Steinbiss Sascha, Torge Antje, Zeillinger Robert, Wölber Linn, Brandt Burkhard

Abstract excerpt

We analyzed variations in the epidermal growth factor receptor (EGFR) gene and 5'-upstream region to identify potential molecular predictors of treatment response in primary epithelial ovarian cancer. Tumor tissues collected during debulking surgery from the prospective multicenter OVCAD study were investigated. Copy number variations in the human endogenous retrovirus sequence human endogenous retrovirus K9...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Ovarian Epithelial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 7

Share to DNA Copy Number Variations

Share to Drug Resistance, Neoplasm

Share to Endogenous Retroviruses

Share to Loss of Heterozygosity

Share to Ovarian Neoplasms

Share to Retroelements

Source

Open in PubMed

Identifiers

PMID: 38709956
DOI: 10.1002/ijc.34976

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of copy numbers of retrotransposons (HERVK) on chromosome 7p11.2 impacts EGFR (Epidermal Growth Factor Receptor)-induced phenotypes for platinum sensitivity and long-term survival in ovarian cancer-A study from the OVCAD consortium.PMID 38709956Read ↗

The Clinical Significance of Genetic Variation in Ovarian Cancer.Semantic proximity Read ↗

Chromosomal copy number and mutational status are required to authenticate ovarian cancer cell lines as appropriate cell models.Semantic proximity Read ↗

Lack of evidence for prognostic value of epidermal growth factor receptor intron-1 CA repeats for oral carcinomas.Semantic proximity Read ↗

Acquired mutations and transcriptional remodeling in long-term estrogen-deprived locoregional breast cancer recurrences.Semantic proximity Read ↗

An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors.Semantic proximity Read ↗

Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts.Semantic proximity Read ↗

Features of the Copy Number Variation of Certain Genes in Tumor Cells in Patients with Serous Ovarian Adenocarcinoma.Semantic proximity Read ↗

Epigenetic biomarkers for clinical outcomes and mechanisms driving emergence of drug resistance in ovarian cancerSemantic proximity Read ↗

Tumour evolution in ovarian cancer using high-throughput genomics technologiesSemantic proximity Read ↗

<i>ERCC5</i> Is a Novel Biomarker of Ovarian Cancer PrognosisSemantic proximity Read ↗

Clinical relevance of circulating ESR1 mutations during endocrine therapy for advanced hormone-dependent endometrial carcinoma.Semantic proximity Read ↗

Tyrosine kinase receptor TIE-1 mediates platinum resistance by promoting nucleotide excision repair in ovarian cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.