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Article

Chromosomal copy number and mutational status are required to authenticate ovarian cancer cell lines as appropriate cell models.

Molecular biology reports - 28 Jun 2024

Stordal Britta, Farrelly Angela M, Hennessy Bryan T

Abstract excerpt

BACKGROUND: The mutational status of ovarian cancer cell line IGROV-1 is inconsistent across the literature, suggestive of multiple clonal populations of the cell line. IGROV-1 has previously been categorised as an inappropriate model for high-grade serous ovarian cancer. METHODS: IGROV-1 cells were obtained from the Netherlands Cancer Institute (IGROV-1-NKI) and the MD Anderson Cancer Centre (IGROV-1-MDA). Cell...

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Identifiers

PMID: 38940864
DOI: 10.1007/s11033-024-09747-4
PMCID: PMC11213756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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