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Article

Morphological basis of the lung adenocarcinoma subtypes

12 Apr 2024

Abstract excerpt

Summary Lung adenocarcinoma (LUAD), which accounts for a large proportion of lung cancers, is divided into five major subtypes based on histologic characteristics. The clinical characteristics, prognosis, and responses to treatments vary among subtypes. Here, we demonstrate that the variations of cell-cell contact energy result in the LUAD subtype-specific morphogenesis. We reproduced the morphologies of the...

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PMID: 38706836
DOI: 10.1016/j.isci.2024.109742

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