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Mitochondrial Mechanisms of Neuronal Cell Death: Potential Therapeutics

6 Jan 2017

Abstract excerpt

Mitochondria lie at the crossroads of neuronal survival and cell death. They play important roles in cellular bioenergetics, control intracellular Ca 2+ homeostasis, and participate in key metabolic pathways. Mutations in genes involved in mitochondrial quality control cause a myriad of neurodegenerative diseases. Mitochondria have evolved strategies to kill cells when they are not able to continue their vital...

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PMID: 28061689
DOI: 10.1146/annurev-pharmtox-010716-105001

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