Article

STING Modulates CD4 T Cell Necroptosis via Activation of PARP-1/PAR Following Acute Systemic Inflammation

2021-09-21

Abstract excerpt

<h4>Background: </h4> Regulated cell death profoundly affects on the progress of inflammatory and immune responses in various acute inflammatory diseases, as seen in sepsis and trauma. However, the mechanisms underlying CD4 T cells death have not yet been fully addressed. <h4>Results: </h4> We demonstrated that interferon genes (STING) promoted excessive Poly (ADP-ribose) polymerase 1 (PARP-1) activity stimulated...

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Literature Corpus work: 8cb6db23-ace9-5139-a3bd-8536f21667c7
DOI: 10.21203/rs.3.rs-895719/v1

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