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GWAS-Significant Loci and Uterine Fibroids Risk: Analysis of Associations, Gene-Gene and Gene-Environmental Interactions.

Frontiers in bioscience (Scholar edition) - 24 Dec 2024

Ponomareva Liubov, Kobzeva Ksenia, Bushueva Olga

Abstract excerpt

BACKGROUND: Uterine fibroids (UF) is the most common benign tumour of the female reproductive system. We investigated the joint contribution of genome-wide association studies (GWAS)-significant loci and environment-associated risk factors to the UF risk, along with epistatic interactions between single nucleotide polymorphisms (SNPs). METHODS: DNA samples from 737 hospitalised patients with UF and 451 controls...

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Case-Control Studies
Epistasis, Genetic
Gene-Environment Interaction
Genome-Wide Association Study
Leiomyoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Uterine Neoplasms

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Identifiers

PMID: 39736018
DOI: 10.31083/j.fbs1604024

Genes

SIRT3
SLK
STN1
FOXO1
TERT
ZNF346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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