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Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18

2 May 2024

Abstract excerpt

The adenovirus-mediated somatic transfer of the embryonic T-box transcription factor 18 (TBX18) gene can convert chamber cardiomyocytes into induced pacemaker cells. However, the translation of therapeutic TBX18-induced cardiac pacing faces safety challenges. Here we show that the myocardial expression of synthetic TBX18 mRNA in animals generates de novo pacing and limits innate and inflammatory immune responses....

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PMID: 38698155
DOI: 10.1038/s41551-024-01211-9

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