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Article

Dissecting the Ca2+ dependence of DesA1 function in Mycobacterium tuberculosis.

FEBS letters - 1 Jul 2024

Savanagouder Mamata, Mukku Ravi Prasad, Kiran Uday, Yeruva Chaitanya Veena, Nagarajan Nandhini, Sharma Yogendra, Raghunand Tirumalai R

Abstract excerpt

Mycobacterium tuberculosis (M. tb) has a complex cell wall, composed largely of mycolic acids, that are crucial to its structural maintenance. The M. tb desaturase A1 (DesA1) is an essential Ca2+-binding protein that catalyses a key step in mycolic acid biosynthesis. To investigate the structural and functional significance of Ca2+ binding, we introduced mutations at key residues in its Ca2+-binding βγ-crystallin...

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PMID: 38697952
DOI: 10.1002/1873-3468.14896

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