Structural insights into the substrate-binding proteins Mce1A and Mce4A from Mycobacterium tuberculosis

Abstract excerpt

Mycobacterium tuberculosis ( Mtb ), which is responsible for more than a million deaths annually, uses lipids as the source of carbon and energy for its survival in the latent phase of infection. Mtb cannot synthesize all of the lipid molecules required for its growth and pathogenicity. Therefore, it relies on transporters such as the mammalian cell entry (Mce) complexes to import lipids from the host across the...

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