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Article

Screening and optimization of shark nanobodies against SARS-CoV-2 spike RBD.

Antiviral research - 1 Jun 2024

Liu Xiaochun, Wang Yanqing, Sun Lishan, Xiao Guokai, Hou Ning, Chen Jin, Wang Wei, Xu Ximing, Gu Yuchao

Abstract excerpt

SARS-CoV-2 continues to threaten human health, antibody therapy is one way to control the infection. Because new SARS-CoV-2 mutations are constantly emerging, there is an urgent need to develop broadly neutralizing antibodies to block the viral entry into host cells. VNAR from sharks is the smallest natural antigen binding domain, with the advantages of small size, flexible paratopes, good stability, and low...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38692413
DOI: 10.1016/j.antiviral.2024.105898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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