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Article

Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity

3 Feb 2023

Abstract excerpt

Despite rapid and ongoing vaccine and therapeutic development, SARS-CoV-2 continues to evolve and evade, presenting a need for next-generation diverse therapeutic modalities. Here we show that nurse sharks immunized with SARS-CoV-2 recombinant receptor binding domain (RBD), RBD-ferritin (RFN), or spike protein ferritin nanoparticle (SpFN) immunogens elicit a set of new antigen receptor antibody (IgNAR) molecules...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36737435
DOI: 10.1038/s41467-023-36106-x

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