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Article

Organophosphate pesticides and PON1 L55M in Parkinson's disease progression.

Environment international - 1 Oct 2017

Paul Kimberly C, Sinsheimer Janet S, Cockburn Myles, Bronstein Jeff M, Bordelon Yvette, Ritz Beate

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) has motor and non-motor features that contribute to its phenotype and functional decline. Organophosphate (OP) pesticides and PON1 L55M, which influences OP metabolism, have been implicated in multiple mechanisms related to neuronal cell death and may influence PD symptom progression. OBJECTIVE: To investigate whether ambient agricultural OP exposure and PON1 L55M influence...

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Identifiers

PMID: 28689109
DOI: 10.1016/j.envint.2017.06.018
PMCID: PMC5600289

Genes

PON1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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