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Article

Enhanced Molecular Response in Myeloproliferative Neoplasms with Complete JAK2V617F Inhibition.

Cancer discovery - 1 May 2024

Celik Hamza, Challen Grant A

Abstract excerpt

SUMMARY: Dunbar, Bowman, and colleagues present here a novel genetic mouse model with inducible and reversible expression of the JAK2V617F mutation in the endogenous locus. Results from this study clearly demonstrate an absolute requirement for myeloproliferative neoplasm-initiating cells for this mutation in their survival and imply that more efficacious inhibitors could be curative for these patients even in...

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Identifiers

PMID: 38690601
DOI: 10.1158/2159-8290.CD-23-1522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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