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Article

Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model.

Blood - 14 Feb 2013

Kubovcakova Lucia, Lundberg Pontus, Grisouard Jean, Hao-Shen Hui, Romanet Vincent, Andraos Rita, Murakami Masato, Dirnhofer Stephan, Wagner Kay-Uwe, Radimerski Thomas, Skoda Radek C

Abstract excerpt

To establish a preclinical animal model for testing drugs with potential effects on myeloproliferative neoplasms (MPNs), we first performed a detailed phenotypic characterization of Cre-inducible transgenic JAK2-V617F mice. Deleting the conditional mouse Jak2-knockout alleles increased erythropoiesis and accentuated the polycythemia vera phenotype, but did not alter platelet or granulocyte levels. In a...

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Identifiers

PMID: 23264594
DOI: 10.1182/blood-2012-03-415646

Genes

JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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