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Article

The Use of Microdosing for In vivo Phenotyping of Cytochrome P450 Enzymes: Where Do We Stand? A Narrative Review.

European journal of drug metabolism and pharmacokinetics - 1 Jul 2024

van der Heijden Lisa T, Opdam Frans L, Beijnen Jos H, Huitema Alwin D R

Abstract excerpt

Cytochrome P450 (CYP) enzymes play a central role in the elimination of approximately 80% of all clinically used drugs. Differences in CYP enzyme activity between individuals can contribute to interindividual variability in exposure and, therefore, treatment outcome. In vivo CYP enzyme activity could be determined with phenotyping. Currently, (sub)therapeutic doses are used for in vivo phenotyping, which can lead...

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Share to Cytochrome P-450 Enzyme Inhibitors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38689161
DOI: 10.1007/s13318-024-00896-2
PMCID: PMC11199305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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