Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human-mouse comparison of the multistage nature of radiation carcinogenesis in a mathematical model.

International journal of cancer - 15 Sept 2024

Imaoka Tatsuhiko, Tanaka Satoshi, Tomita Masanori, Doi Kazutaka, Sasatani Megumi, Suzuki Keiji, Yamada Yutaka, Kakinuma Shizuko, Kai Michiaki

Abstract excerpt

Mouse models are vital for assessing risk from environmental carcinogens, including ionizing radiation, yet the interspecies difference in the dose response precludes direct application of experimental evidence to humans. Herein, we take a mathematical approach to delineate the mechanism underlying the human-mouse difference in radiation-related cancer risk. We used a multistage carcinogenesis model assuming a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Dose-Response Relationship, Radiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Theoretical

Share to Mutation

Share to Neoplasms, Radiation-Induced

Share to Radiation, Ionizing

Share to Species Specificity

Source

Identifiers

PMID: 38688826
DOI: 10.1002/ijc.34987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human-mouse comparison of the multistage nature of radiation carcinogenesis in a mathematical model.PMID 38688826Read ↗

A model for dose rate and duration of exposure effects in radiation carcinogenesis.Semantic proximity Read ↗

Implications of the analysis of epidemiological data using a two-mutation carcinogenesis model for radiation risks.Semantic proximity Read ↗

Multistage carcinogenesis: Impact of age, genetic, and environmental factors on the incidence of malignant mesothelioma.Semantic proximity Read ↗

Mouse models for radiation-induced cancersSemantic proximity Read ↗

Multistage carcinogenesis modeling and the initiation event.Semantic proximity Read ↗

A generalized theory of age-dependent carcinogenesisSemantic proximity Read ↗

MECHANISMS OF RADIATION CARCINOGENESIS: WHAT IS REALLY INDUCED?Semantic proximity Read ↗

Aging and age-related health effects of ionizing radiationSemantic proximity Read ↗

Estimation of the hereditary risks of exposure to ionizing radiation: history, current status, and emerging perspectives.Semantic proximity Read ↗

DETECTION OF TRANSGENERATIONAL GENETIC EFFECTS BASED ON WHOLE-GENOME SEQUENCING IN THE MOUSE MODEL.Semantic proximity Read ↗

Mouse Genomic Associations with <i>Ex Vivo</i> Sensitivity to Simulated Space RadiationSemantic proximity Read ↗

Mechanistic and genetic studies of radiation tumorigenesis in the mouse--implications for low dose risk estimation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.