Mechanistic and genetic studies of radiation tumorigenesis in the mouse--implications for low dose risk estimation.

Abstract excerpt

Radiation cancer risk estimates remain firmly based upon epidemiological data. Experimental validation of the fundamental aspects of these risk estimates relies on animal studies. In particular, animal model systems for radiation carcinogenesis can provide data for mechanistic modelling approaches to risk estimation. The accuracy and validity of risk estimation models developed will depend upon the extent of our...

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