Article

Mouse Genomic Associations with <i>Ex Vivo</i> Sensitivity to Simulated Space Radiation

2022-03-05

Abstract excerpt

Exposure to ionizing radiation is considered by NASA to be a major health hazard for deep space exploration missions. Ionizing radiation sensitivity is modulated by both genomic and environmental factors. Understanding their contributions is crucial for designing experiments in model organisms, evaluating the risk of deep space (i.e. high-linear energy transfer, or LET, particle) radiation exposure in astronauts,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 367b459b-91a8-50fa-96c6-2e280ad6d52b
DOI: 10.1101/2022.03.03.482929

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mouse Genomic Associations with <i>Ex Vivo</i> Sensitivity to Simulated Space RadiationDOI 10.1101/2022.03.03.482929Read

Dose, LET and Strain Dependence of Radiation-Induced 53BP1 Foci in 15 Mouse Strains Ex Vivo Introducing Novel DNA Damage MetricsSemantic proximity Read

Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolomeSemantic proximity Read

Mouse models for radiation-induced cancersSemantic proximity Read

Understanding Cancer Development Processes after HZE-Particle Exposure: Roles of ROS, DNA Damage Repair and InflammationSemantic proximity Read

Radiation Type- and Dose-Specific Transcriptional Responses across Healthy and Diseased Mammalian TissuesSemantic proximity Read

Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility.Semantic proximity Read

Global Gene Expression Response in Mouse Models of DNA Repair Deficiency after Gamma Irradiation.Semantic proximity Read

Identification of Differential Gene Expression Patterns after Acute Exposure to High and Low Doses of Low-LET Ionizing Radiation in a Reconstituted Human Skin TissueSemantic proximity Read

The Dose Window for Radiation-Induced Protective Adaptive ResponsesSemantic proximity Read

Time- and sex-dependent delayed effects of acute radiation exposure manifest via miRNA dysregulationSemantic proximity Read

Development of a Model of the Acute and Delayed Effects of High Dose Radiation Exposure in Jackson Diversity Outbred Mice; Comparison to Inbred C57BL/6 MiceSemantic proximity Read

Effects of 1 GeV/nucleon ⁵⁶Fe particles on longevity, carcinogenesis and neuromotor ability in Atm-deficient mice.Semantic proximity Read