Article
Gray matter volume in women with the BRCA mutation with and without ovarian removal: evidence for increased risk of late-life Alzheimer's disease or dementia.
Menopause (New York, N.Y.) - 1 Jul 2024
Witt Suzanne T, Brown Alana, Gravelsins Laura, Engström Maria, Classon Elisabet, Lykke Nina, Åvall-Lundqvist Elisabeth, Theodorsson Elvar, Ernerudh Jan, Kjölhede Preben, Einstein Gillian
Abstract excerpt
OBJECTIVE: Ovarian removal prior to spontaneous/natural menopause (SM) is associated with increased risk of late life dementias including Alzheimer's disease. This increased risk may be related to the sudden and early loss of endogenous estradiol. Women with breast cancer gene mutations (BRCAm) are counseled to undergo oophorectomy prior to SM to significantly reduce their risk of developing breast, ovarian, and...
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