Long-term ovarian hormone deprivation alters functional connectivity, brain neurochemical profile and white matter integrity in the Tg2576 amyloid mouse model of Alzheimer's disease.

doi:10.1016/j.neurobiolaging.2021.02.011

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Long-term ovarian hormone deprivation alters functional connectivity, brain neurochemical profile and white matter integrity in the Tg2576 amyloid mouse model of Alzheimer's disease.

Neurobiology of aging - 1 Jun 2021

Kara Firat, Belloy Michael E, Voncken Rick, Sarwari Zahra, Garima Yadav, Anckaerts Cynthia, Langbeen An, Leysen Valerie, Shah Disha, Jacobs Jules, Hamaide Julie, Bols Peter, Van Audekerke Johan, Daans Jasmijn, Guglielmetti Caroline, Kantarci Kejal, Prevot Vincent, Roßner Steffen, Ponsaerts Peter, Van der Linden Annemie, Verhoye Marleen

Abstract excerpt

Premenopausal bilateral ovariectomy is considered to be one of the risk factors of Alzheimer's disease (AD). However, the underlying mechanisms remain unclear. Here, we aimed to investigate long-term neurological consequences of ovariectomy in a rodent AD model, TG2576 (TG), and wild-type mice (WT) that underwent an ovariectomy or sham-operation, using in vivo MRI biomarkers. An increase in osmoregulation and...

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PMID: 33765427
DOI: 10.1016/j.neurobiolaging.2021.02.011
PMCID: PMC8312737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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