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Article

Long-term effects of bilateral oophorectomy on brain aging: unanswered questions from the Mayo Clinic Cohort Study of Oophorectomy and Aging.

Women's health (London, England) - 1 Jan 2009

Rocca Walter A, Shuster Lynne T, Grossardt Brandon R, Maraganore Demetrius M, Gostout Bobbie S, Geda Yonas E, Melton L Joseph

Abstract excerpt

In the Mayo Clinic Cohort Study of Oophorectomy and Aging, women who had both ovaries removed before reaching natural menopause experienced a long-term increased risk of parkinsonism, cognitive impairment or dementia, and depressive and anxiety symptoms. Here, we discuss five possible mechanistic interpretations of the observed associations; first, the associations may be non-causal because they result from the...

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Source

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Identifiers

PMID: 19102639
DOI: 10.2217/17455057.5.1.39
PMCID: PMC2716666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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