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Article

Considering Clinical Implementation of Polygenic Scores in Hereditary Cancer Risk Assessment: Recipients' Perspectives on Influencing Factors and Strategies.

The patient - 1 Nov 2025

Purvis Rebecca, Taylor Natalie, James Paul, Young Mary-Anne, Forrest Laura E

Abstract excerpt

BACKGROUND: Polygenic scores (PGS) capture a proportion of the genomic liability for cancer in unselected and high-risk cohorts, with meaningful application in improving risk-stratified screening and management. However, there are significant evidence gaps regarding future clinical implementation. Despite being key interest-holders, recipient views are underrepresented. The objective of this study was to explore...

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Identifiers

PMID: 40580369
DOI: 10.1007/s40271-025-00747-5
PMCID: PMC12559137

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