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Article

Identifying somatic fingerprints of cancers defined by germline and environmental risk factors.

Genetic epidemiology - 1 Dec 2024

Chakraborty Saptarshi, Guan Zoe, Kostrzewa Caroline E, Shen Ronglai, Begg Colin B

Abstract excerpt

Numerous studies over the past generation have identified germline variants that increase specific cancer risks. Simultaneously, a revolution in sequencing technology has permitted high-throughput annotations of somatic genomes characterizing individual tumors. However, examining the relationship between germline variants and somatic alteration patterns is hugely challenged by the large numbers of variants in a...

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Identifiers

PMID: 38686586
DOI: 10.1002/gepi.22565
PMCID: PMC11522022

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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