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Article

A conceptual and methodological framework for investigating etiologic heterogeneity.

Statistics in medicine - 20 Dec 2013

Begg Colin B, Zabor Emily C, Bernstein Jonine L, Bernstein Leslie, Press Michael F, Seshan Venkatraman E

Abstract excerpt

Cancer has traditionally been studied using the disease site of origin as the organizing framework. However, recent advances in molecular genetics have begun to challenge this taxonomy, as detailed molecular profiling of tumors has led to discoveries of subsets of tumors that have profiles that possess distinct clinical and biological characteristics. This is increasingly leading to research that seeks to...

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Identifiers

PMID: 23857589
DOI: 10.1002/sim.5902
PMCID: PMC4104361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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