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Profiling Phenotypic Heterogeneity of Circulating Tumor Cells through Spatially Resolved Immunocapture on Nanoporous Micropillar Arrays.

ACS nano - 12 Nov 2024

Lu Lianyu, Wang Yaohui, Ding Yue, Wang Yuqing, Zhu Zhi, Lu Jinsong, Yang Liu, Zhang Peng, Yang Chaoyong

Abstract excerpt

The phenotype of circulating tumor cells (CTCs) offers valuable insights into monitoring cancer metastasis and recurrence. While microfluidics presents a promising approach for capturing these rare cells in blood, the phenotypic profiling of CTCs remains technically challenging. Herein, we developed a nanoporous micropillar array chip enabling highly efficient capture and in situ phenotypic analysis of CTCs...

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PMID: 39492759
DOI: 10.1021/acsnano.4c08893

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