Article
Molecular profiling of single circulating tumor cells from lung cancer patients.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2016
Park Seung-Min, Wong Dawson J, Ooi Chin Chun, Kurtz David M, Vermesh Ophir, Aalipour Amin, Suh Susie, Pian Kelsey L, Chabon Jacob J, Lee Sang Hun, Jamali Mehran, Say Carmen, Carter Justin N, Lee Luke P, Kuschner Ware G, Schwartz Erich J, Shrager Joseph B, Neal Joel W, Wakelee Heather A, Diehn Maximilian, Nair Viswam S, Wang Shan X, Gambhir Sanjiv S
Abstract excerpt
Circulating tumor cells (CTCs) are established cancer biomarkers for the "liquid biopsy" of tumors. Molecular analysis of single CTCs, which recapitulate primary and metastatic tumor biology, remains challenging because current platforms have limited throughput, are expensive, and are not easily translatable to the clinic. Here, we report a massively parallel, multigene-profiling nanoplatform to compartmentalize...
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